The 2016 U.S. Open victor, who had been the favourite at Augusta before slipping on a staircase and landing heavily on his back, said he came into the Wells Fargo cold but was pleased with how he held up physically after the lay-off.
The only rival with a chance to catch Harman was Spaniard Jon Rahm, playing on the sixth anniversary of the death of Spanish legend Seve Ballesteros.
Up first was the left-hander Harman, whose second shot to the par-5 finisher wound up well left of the green.
"It's surreal. I three-putted that 15th hole, I knew it was going to be tough to birdie that last couple, but I just stuck to my game plan and did the best I could".
The 34-year-old Lashley topped the PGA Tour Latinoamerica money list last season to earn a spot on the Web.com Tour, where the top 10 earners at the end of the season will earn PGA Tour cards. "Not much has changed".
"No. 2 is really sweet", Harman said, referring to his second PGA victory and the first PGA even in Wilmington since 1971. "The first couple of days I didn't play great but then on the weekend I played really nicely so I'm happy where the game is going into next week". When he finished his final round, he headed to the clubhouse with a share of the lead at 9-under.
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"I actually thought, man, this is a real bomber's paradise", he said. "My tee shot was pretty good all day, I just have to work on my putting".
Rahm made a bogey at 15 to fall one back of Perez and Johnson but could only muster three closing pars, his pitch for eagle miss at 18 ensuring Harman's win. He shot 40 on the back nine and wound up tied for 12th at 283 following a 75.
Daly bogeyed the final three holes for a 3-under 69 and a one-stroke victory over Kenny Perry and Tommy Armour III.
THE WOODLANDS, Texas (AP) - John Daly held on to win the Insperity Invitational for his first PGA Tour Champions title.
Johnson would have been only the fourth PGA player in eight seasons to win after making the cut on the number, the first since Brandt Snedeker past year and the first at this event since Rory McIlroy in 2010. He finished at 14-under 202. Perry had a 69, and Armour shot 67. Moments later friends and colleagues including players Esteban Toledo and Michael Allen ran out to spray their pal with champagne.
Kevin Sutherland was fourth at 11 under after a 67.